Protection against β-amyloid induced abnormal synaptic function and cell death by Ginkgolide J
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چکیده
منابع مشابه
Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin
β-amyloid (Aβ) oligomers have been closely implicated in the pathogenesis of Alzheimer's disease (AD). We found, for the first time, that bis(heptyl)-cognitin, a novel dimeric acetylcholinesterase (AChE) inhibitor derived from tacrine, prevented Aβ oligomers-induced inhibition of long-term potentiation (LTP) at concentrations that did not interfere with normal LTP. Bis(heptyl)-cognitin also pre...
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ژورنال
عنوان ژورنال: Neurobiology of Aging
سال: 2009
ISSN: 0197-4580
DOI: 10.1016/j.neurobiolaging.2007.05.025